An investigation has been launched into claims of dysfunction and bullying at the National Mental Health Commission.

A report published in The Saturday Paper set out a series of allegations relating to the commission, which was set up just over a decade ago to provide policy advice on mental health.

Health Minister Mark Butler said on Monday he had initiated an independent investigation into the claims and the commission's CEO Christine Morgan had voluntarily stepped aside.

The investigation will consider whether the matters raised in the report could be substantiated, as well as conduct a "culture and capability review" to ensure the commission is able to provide a safe working environment and has the capability to perform its role.

There will also be a "functional and efficiency review" to ensure the commission can be financially sustainable.

The independent investigation will be led by Professor Deb Picone, an experienced health administrator.

The nation's deputy chief medical officer Dr Ruth Vine has been appointed interim CEO of the commission.

"As minister I take allegations of this nature seriously and will prioritise ensuring a safe working environment for staff," Mr Butler said.