The death of a 14-year-old boy while awaiting specialised gender-affirming treatment is unbelievably tragic, the acting NSW premier says.

Prue Car on Monday promised to get to the bottom of the case of Noah O'Brien, who took his own life in January.

His death followed a reported referral for - but not provision of - specialist gender support at The Children's Hospital in Sydney's Westmead.

"It's obviously unbelievably tragic," the acting premier told reporters.

"No one should feel like they're in that position."

Noah's case is part of a Four Corners expose of the Sydney gender clinic that points to severe staffing issues and a ballooning waiting list.

Ms Car expected Australians would witness "very concerning and really distressing" reports about the clinic.

The state government remained committed to protecting and supporting vulnerable young people who reached out for help amid a difficult and trying time in their lives, she said.

"We obviously need to make sure that what is quite a vulnerable cohort of young people, in particular, is protected and supported," she said.

Increased demand for gender-affirming care is also apparent at Monash Health's Gender Clinic - Victoria's specialist public health service for the trans, gender-diverse and non-binary community.

Clients were warned in February of an 18-month wait from referral to begin the booking process and of a "very long" waitlist for surgeries.

NSW Health Minister Ryan Park is expected to address the ABC reports on Tuesday morning.

The state's health department has been contacted for comment.

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