Police have charged two men with serious assault after they spat on paramedics in separate incidents in southeast Queensland over the weekend.

A senior Gold Coast paramedic has labelled recent attacks on his colleagues as "disgusting" after two men allegedly spat on officers at the weekend.

Two patients have been charged with seriously assaulting a public officer in separate incidents at police watchhouses in southeast Queensland.

Police say a 21-year-old man spat on the arm of an officer at Surfers Paradise in the early hours of Saturday morning.

Another man, 25, spat in the face of female paramedic as she tried to treat him at Caboolture on Sunday afternoon.

Gold Coast assistant commissioner John Hammond said such behaviour was completely out of line.

"Any assault, no matter how serious, is totally unacceptable," he said.

"That type of behaviour is disgusting really."

Four people have been charged over attacks on Queensland paramedics in the past three weeks.

A 21-year-old Tully man was being treated after a car crash when he became agitated, allegedly kicking and spitting on paramedics and police officers.

A woman, 34, faced court after allegedly kicking medical officers in the back of an ambulance as she was being taken to Royal Brisbane and Women's Hospital.

Queensland Ambulance Service say there have been around 150 cases of physical assault against paramedics from July 2015 to the end of January this year.

The maximum penalty for assaulting a public officer is 14 years in jail.