The provision of gender-affirming care in NSW is not working and has to improve, the state's health minister says.

The main gender-affirming clinic for adolescents in Sydney has come under scrutiny, with the ABC revealing it has only taken on three new patients this year.

That statistic is a concern for Health Minister Ryan Park, as are reports some children and parents don't feel safe with the level of care provided.

"It's certainly not a system that is working for people and I want to improve that," Mr Park said on Tuesday.

Sydney Children's Hospitals Network, which operates the decade-old clinic, has recently found staffing difficult after a swathe of resignations.

The exodus was prompted by controversial research endorsed by the hospital hierarchy and weaponised by anti-transgender activists, the ABC reported.

That research will now be independently reviewed by health research body the Sax Institute, Mr Park said.

A long-promised clinic in Sydney's east would also be established within nine months and clinicians on the ground would be better consulted, he said.

"We've got a lot of work to do in this space," he said.

"Whilst it is an emerging area of healthcare, NSW needs to be leading this and needs to be at the forefront."

The hospital network said its service continued to provide care to patients, amid increased demand in recent years for health services supporting trans and gender-diverse young people and their families.

To meet the need, the state health department is developing a framework for local networks to provide evidence-based trans and gender-diverse health care.

Growing demand for care is also causing long delays at Victoria's specialist public health service for the trans, gender-diverse and non-binary community.

Clients referred to Monash Health's Gender Clinic were warned in February of an 18-month wait to begin the booking process and of a "very long" waitlist for surgery.